The Detailed Information of Protein
| Protein ID: | ICDB_Pro_1720 |
|---|---|
| Protein Name: | Inositol 1;4;5-triphosphate receptor associated 1 |
| Function: | Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. |
| Sequence: | MGMDLTCPFGISPACGAQASWSIFGADAAEVPGTRGHSQQEAAMPHIPEDEEPPGEPQAAQSPAGQGPPAAGVSCSPTPTIVLTGDATSPEGETDKNLANRVHSPHKRLSHRHLKVSTASLTSVDPAGHIIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSPGDSPSAVSPNLSPSASPTSSRSNSLTVPTPPGLDVCSGPPSPLPGAPPQQKGDEADVSSPHPGEPNVPKGLADRKQNDQRKVSQGRLAPRPPPVEKSKEIAIEQKENFDPLQYPETTPKGLAPVTNSSGKMALNSPQPGPVESELGKQLLKTGWEGSPLPRSPTQDAAGVGPPASQGRGPAGEPMGPEAGSKAELPPTVSRPPLLRGLSWDSGPEEPGPRLQKVLAKLPLAEEEKRFAGKAGGKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILMRNQNLVGLKLPDLSEAAEQEKGLPSELSPAIEEEESKSGLDVMPNISDVLLRKLRVHRSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLTLGKNMPRRRVSVAVVPKFNALNLPGQTPSSSSIPSLPALSESPNGKGSLPVTSALPALLENGKTNGDPDCEASAPALTLSCLEELSQETKARMEEEAYSKGFQEGLKKTKELQDLKEEEEEQKSESPEEPEEVEETEEEEKGPRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAVMLVLTVVLGLYNSYNSCAEQADGPLGRSTCSAAQRDSWWSSGLQHEQPTEQ |
| Gene Name: | IRAG1; IRAG; JAW1L; MRVI1 |
| Organism: | Homo sapiens (Human) |
| Length: | 904 | PDB: |
| Ligand Binding: |
1. DICL_CP
2. DICL_Pep
|
| AlphaFoldDB: | AF-Q9Y6F6-F1-model_v4.pdb |
| Binding site: | |
| Disease: | Scalp Dermatosis and Fibroepithelial Polyp Of The Anus |
| Location: | Expressed in the colon; rectum; and cultured colonic smooth muscle. Detected in various cancer cell lines. |
| DOI ID: | 10.1038/sj.onc.1202419; 10.1038/ng1285; 10.1038/nature04632; 10.1101/gr.2596504; 10.1074/jbc.m313365200; 10.1182/blood-2005-10-026294; 10.4161/cbt.6.3.3704; 10.1016/j.jprot.2013.11.014 |
| RefSeq: | NP_001092049.2 [Q9Y6F6-9]; NP_001093633.1 [Q9Y6F6-5]; NP_001093637.1 [Q9Y6F6-6]; NP_001193809.1 [Q9Y6F6-8]; NP_001193810.1 [Q9Y6F6-6]; NP_569056.4 [Q9Y6F6-7] |